Recommended natural products in Alzheimer's disease based on traditional Persian medicine

Background: Alzheimerchr('39')s disease is the most common cause of dementia, especially in elderlies. Its exact pathogenesis is not yet known and existing therapies do not have enough efficacy. Therefore, the use of complementary therapies such as traditional Persian medicine for improving memory function is increasing. Objective: The aim of this study is evaluating recommended natural products in important traditional Persian medicine textbooks. Methods: For this purpose, keywords such as "Nesyan" (ie: oblivion, amnesia), "Hafezeh" (ie: memory), "Zekr" (ie: mention) and "Faramoushi" (ie: forgetfulness( were used to search in recommended prescription in important traditional Persian medicine textbooks. Then, the most repeated plants were extracted from the prescription and evaluated for their pharmacological properties recently published articles cited in the scientific databases such as Google Scholar, PubMed, Medline, and Scopus. Results: 262 natural products were in 96 evaluated prescription, 40 natural products were more repeated. These products were introduced in the table. Besides, their neuroprotective effects, antioxidant effects, and anti-Alzheimerchr('39')s disease effect were also included in the table. Conclusion: Based on these results, traditional Persian has introduced many treatments for Alzheimerchr('39')s disease, which requires clinical studies to prove or disprove their efficacy and safety.